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Cardinals Rally From 17 Down but Fall 36-30 at Unbeaten 49ers

Jacoby Brissett threw for 280 yards and Arizona got within two in the fourth quarter before a late George Kittle touchdown. The Cardinals are 1-2.

Lena Quill

September 28, 20262 min read

Football Comeback - illustration, Jake Team LLC

The Arizona Cardinals spent most of Sunday chasing the San Francisco 49ers, and nearly caught them. Arizona came back from a 23-6 deficit to get within two points in the fourth quarter before falling 36-30 at Levi's Stadium.

Down early

San Francisco scored on the third play of the game when Brock Purdy's short pass to Mike Evans was flipped back to Deebo Samuel for an 82-yard touchdown, and the 49ers led 14-0 in the second quarter. Chad Ryland kicked field goals of 26 and 41 yards for Arizona, but a 57-yarder by Eddy Pineiro sent San Francisco into halftime up 17-6.

A Christian McCaffrey touchdown run made it 23-6 in the third quarter.

The comeback

Jacoby Brissett led the push back. His 5-yard touchdown pass to Michael Wilson late in the third quarter and a 1-yard touchdown pass to Jeremiyah Love early in the fourth cut the deficit to 23-20. After George Kittle's 10-yard touchdown catch for San Francisco, Brissett ran in from a yard out with 2:51 left to make it 29-27.

The 49ers answered with Purdy's 20-yard touchdown pass to Kittle with 1:31 remaining. Ryland's 49-yard field goal with 34 seconds left closed the gap to six, and that was as close as Arizona got.

Leaders

Brissett completed 38 of 52 passes for 280 yards and two touchdowns and ran for another score. Love ran 21 times for 90 yards, and Wilson caught 11 passes for 89 yards and a touchdown. Ryland made three field goals, and Andrew Wingard led the defense with 10 tackles.

Purdy threw for 297 yards and four touchdowns for San Francisco, which improved to 3-0. Arizona is 1-2.

Sources

ESPN box score, Cardinals at 49ers, Sept. 27, 2026

The Associated Press, "Purdy throws 4 TD passes to lead the injury-depleted 49ers to a 36-30 win vs. the Cardinals" (Sept. 27, 2026)

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Lena Quill

Lena Quill covers Queen Creek high school and area college sports.

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